Understandings:
- The liver removes toxins from the blood and detoxifies them.
- Components of red blood cells are recycled by the liver.
- The breakdown of erythrocytes starts with phagocytosis of red blood cells by Kupffer cells.
- Iron is carried to the bone marrow to produce hemoglobin in new red blood cells.
- Surplus cholesterol is converted to bile salts.
- Endoplasmic reticulum and Golgi apparatus in hepatocytes produce plasma proteins.
- The liver intercepts blood from the gut to regulate nutrient levels.
- Some nutrients in excess can be stored in the liver.
Applications and skills:
- Application: Causes and consequences of jaundice.
- Application: Dual blood supply to the liver and differences between sinusoids and capillaries.
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Theory of knowledge:
- Excessive alcohol consumption may cause liver cirrhosis. Are attitudes to drugs and alcohol an example of something that is relative to culture? Is all knowledge dependent on culture?
Aims:
- Aim 6: Temporary mounts of hepatocytes can be prepared from fresh liver.
- Aim 8: Given the pressure on health resources, especially the availability of organs for transplant, should an alcoholic be allowed a liver transplant?
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